Martin Tik

Martin Tik (martin.tik@meduniwien.ac.at) is Principal Investigator at the Medical University of Vienna.  He is working at the Center of Medical Physics and Biomedical Engineering (MR Physics Division) and involved in collaborative projects with the Departments of Psychiatry and Psychotherapy, Neurology and multiple clinics at the Vienna General Hospital, Sunnybrooks Hospital (Toronto), Hong Kong Polytechnic University, Ludwig Maximilian University of Munich and Stanford University.
Important research milestones include dose-dependency and network specificity of online TMS effects, insights into the role of dopamine and dopaminergic pathways in insightful problem solving (Aha moments) and fMRI connectivity changes linked to affective disorders and remission. He is a member of the Management Commitee in COST Action 18138 - RISE Network in Peripartum Depression Disorder and aims to broaden applications of TMS treatment to new patient populations and importantly tailoring transcranial magnetic stimulation to individual patients needs towards a precision medicine approach to brain stimulation.
His main research interests are at the interface of fMRI brain mapping and TMS brain stimulation. Recent Publications include offline rTMS/fMRI studies to reveal network-specific changes after brain stimulation and importantly online TMS/fMRI work demonstrating target enagement during stimulation.

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Recent Publications

Grosshagauer S, Woletz M, Vasileiadi M, Linhardt D., Nohava L., Schuler A, Windischberger C., Williams N., Tik M.Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects. Molecular Psychiatry (IF=12.0). 2024

Vasileiadi M, Schuler AL, Woletz M, Linhardt D, Windischberger C, Tik M Functional connectivity explains how neuronavigated TMS of posterior temporal subregions differentially affect language processing”. Brain Stimulation (IF=9.2). 2023.

Tik M, Woletz M, Schuler AL, Vasileiadi M, Cash RFH, Zalesky A, Lamm C, Windischberger C. Acute TMS/fMRI response explains offline TMS network effects - An interleaved TMS-fMRI study. Neuroimage. 2023 Feb 15;267:119833. Epub 2022 Dec 23. PMID: 36572133.

Geissberger N¹ & Tik M¹, Sladky R, Woletz M, Schule AL, Willinger D,' Windischberger C. Reproducibility of amygdala activation in facial emotion processing at 7T. Neuroimage. 2020 Jan 26:116585. 2020.

Tik M¹ & Sladky R¹, Luft CDB, Willinger D, Hoffmann A, Banissy MJ, Bhattacharya J, Windischberger C. Ultra-high-field fMRI insights on insight: Neural correlates of the Aha!-moment. Human Brain Mapping 2018 Apr 17. 2018.

Tik, M, Hoffmann A, Sladky R, Tomova L, Hummer A, Navarro de Lara L, Bukowski H, Pripfl J, Biswal B, Lamm C, Windischberger C. (2017). Towards understanding rTMS mechanism of action: Stimulation of the DLPFC Causes Network-specific Increase in Functional Connectivity. NeuroImage.

Tik M, Woletz M, Navarro de Lara L, Sladky R, Hoffmann A, Hummer A, Windischberger C. Mapping TMS local and remote immediate effects by concurrent TMS/fMRI using a dedicated high-sensitivity coil array. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation. 2017 Mar 1;10(2):489-91.

Navarro de Lara L¹ & Tik M¹, Woletz M, Frass-Kriegl R, Moser E, Laistler E, Windischberger C. High-sensitivity TMS/fMRI of the Human Motor Cortex Using a Dedicated Multichannel MR Coil. NeuroImage. 2017 Apr 15;150:262-9.

¹ authors contributed equally to this manuscript

Conference proceedings & preprints

Tik M, Woletz M, Princic M, Schuler A, Geissberger N, Hummer A, Windischberger A. Individualizing Brainstimulation through concurrent TMS/fMRI. 3rd International Brain Stimulation Conference - Vancouver, Canada. 2019.

Tik M, Woletz M, G Kranz, D Pfabigan, N Geissberger, R Sladky, C Kraus, B Auer, T Vanicek, K Paul, R Lanzenberger, C Lamm, Windischberger C. Remission from depression and tms over left DLPFC share the same network connectivity changes. 3rd International Brain Stimulation Conference - Vancouver, Canada. 2019.

Peer-reviewed Journal Papers

Tik M, Woletz M, Schuler AL, Vasileiadi M, Cash RFH, Zalesky A, Lamm C, Windischberger C. Acute TMS/fMRI response explains offline TMS network effects - An interleaved TMS-fMRI study. Neuroimage. 2023 Feb 15;267:119833. Epub 2022 Dec 23. PMID: 36572133.

Mizutani-Tiebel Y, Tik M, Chang KY, Padberg F, Soldini A, Wilkinson Z, Voon CC, Bulubas L, Windischberger C, Keeser D. Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous Studies. Front Psychiatry. 2022.

Linhardt D, Pawloff M, Hummer A, Woletz M, Tik M, Ritter M, Schmidt-Erfurth U, Windischberger C. Combining stimulus types for improved coverage in population receptive field mapping. NeuroImage. 2021.

Linhardt D, Pawloff M, Woletz M, Hummer A, Tik M, Vasileiadi M, Ritter M, Lerma-Usabiaga G, Schmidt-Erfurth U, Windischberger C. Intrasession and Intersession Reproducibility of Artificial Scotoma pRF Mapping Results at Ultra-High Fields. eNeuro. 2022.

Geissberger N & Tik M, Sladky R, Woletz M, Schule AL, Willinger D, Windischberger C. Reproducibility of amygdala activation in facial emotion processing at 7T. Neuroimage. 2020 Jan 26:116585. 2020.

Kraus C, Seiger R, Pfabigan D, Sladky R, Tik M, Paul K, Woletz M, Gryglewski G, Vanicek T, Komorowski A, Kasper S, Lamm C, Windischberger C, Lanzenberger R. Hippocampal Subfields in Acute and Remitted Depression - an Ultra-High Field Magnetic Resonance Imaging Study.. Int J Neuropsychopharmacol. 2019 Jun 6. pii: pyz030. doi: 10.1093/ijnp/pyz030. 2019.

Rütgen M, Pletti C, Tik M, Kraus C, Pfabigan DM, Sladky R, Klöbl M, Woletz M, Vanicek T, Windischberger C, Lanzenberger R, Lamm C. Antidepressant treatment, not depression, leads to reductions in behavioral and neural responses to pain empathy. Transl Psychiatry. 2019 Jun 7;9(1):164. doi: 10.1038/s41398-019-0496-4. 2019.

Schuler A, Tik M, Sladky R, Luft CDB, Hoffmann A, Woletz M, Zioga I, Bhattacharya J, Windischberger C. Modulations in resting state networks of subcortical structures linked to creativity. Neuroimage. 2019 Mar 29;195:311-319. 2019.

Woletz M, Hoffmann A, Tik M, Sladky R, Lanzenberger R, Robinson S, Windischberger C. Beware detrending: Optimal preprocessing pipeline for low-frequency fluctuation analysis. Hum Brain Mapp. 2019 Apr 1;40(5):1571-1582. 2019.

Hummer A, Ritter M, Woletz M, Ledolter AA, Tik M, Dumoulin SO, Holder GE, Schmidt-Erfurth U, Windischberger C. Artificial scotoma estimation based on population receptive field mapping.. Neuroimage. 2018 Apr 1;169:342-351. 2018.

Kranz GS, Hahn A, Kaufmann U, Tik M, Ganger S, Seiger R, Hummer A, Windischberger C, Kasper S, Lanzenberger R. Effects of testosterone treatment on hypothalamic neuroplasticity in female-to-male transgender individuals.. Brain Struct Funct. 2018 Jan;223(1):321-328. 2018.

Kraus C, Klöbl M, Tik M, Auer B, Vanicek T, Geissberger N, Pfabigan DM, Hahn A, Woletz M, Paul K, Komorowski A, Kasper S, Windischberger C, Lamm C, Lanzenberger R. The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI. Mol Psychiatry. 2018 Feb 8. 2018.

Tik M, Sladky R, Luft CDB, Willinger D, Hoffmann A, Banissy MJ, Bhattacharya J, Windischberger C. Ultra-high-field fMRI insights on insight: Neural correlates of the Aha!-moment. Human Brain Mapping 2018 Apr 17. 2018.

Höflich A, Ganger S, Tik M, Hahn A, Kranz GS, Vanicek T, Spies M, Kraus C, Windischberger C, Kasper S, Winkler D, Lanzenberger R. Imaging the neuroplastic effects of ketamine with VBM and the necessity of placebo control. Neuroimage Feb 15;147:198-203, 2017.

Kranz GS, Seiger R, Kaufmann U, Hummer A, Hahn A, Ganger S, Tik M, Windischberger C, Kasper S, Lanzenberger R. Effects of sex hormone treatment on white matter microstructure in individuals with gender dysphoria. Neuroimage Feb 13;150:60-67, 2017.

Navarro de Lara L &, Tik M, Woletz M, Frass-Kriegl R, Moser E, Laistler E, Windischberger C.. High-sensitivity TMS/fMRI of the Human Motor Cortex Using a Dedicated Multichannel MR Coil. NeuroImage. 150:262-9. 2017.

Sladky R, Geissberger N, Pfabigan DM, Kraus C, Tik M, Woletz M, Paul K, Vanicek T, Auer B, Kranz GS, Lamm C, Lanzenberger R, Windischberger C. Unsmoothed functional MRI of the human amygdala and bed nucleus of the stria terminalis during processing of emotional faces. Neuroimage Jan 17, 2017.

Spies M, Kraus C, Geissberger N, Auer B, Klöbl M, Tik M, Stürkat IL, Hahn A, Woletz M, Pfabigan DM, Kasper S, Lamm C, Windischberger C, Lanzenberger R. Default mode network deactivation during emotion processing predicts early antidepressant response. Transl Psychiatry Jan 24;7(1):e1008, 2017.

Tik M, Hoffmann A, Sladky R, Tomova L, Hummer A, Navarro de Lara L, Bukowski H, Pripfl J, Biswal B, Lamm C, Windischberger C. Towards understanding rTMS mechanism of action: Stimulation of the DLPFC causes network-specific increase in functional connectivity. Neuroimage. 2017 Sep 11. 2017.

Hummer A, Ritter M, Tik M, Ledolter AA, Woletz M, Holder GE, Dumoulin SO, Schmidt-Erfurth U, Windischberger C. Eyetracker-based gaze correction for robust mapping of population receptive fields. Neuroimage Nov 15;142:211-224, 2016.

Navarro de Lara LI, Tik M, Woletz M, Frass-Kriegl R, Moser E, Laistler E, Windischberger C. High-sensitivity TMS/fMRI of the Human Motor Cortex Using a Dedicated Multichannel MR Coil. Neuroimage Feb 22;150:262-269, 2016.

Sladky R, Stepniczka I, Boland E, Tik M, Lamm C, Hoffmann A, Buch JP, Niedermeier D, Field J, Windischberger C. Neurobiological differences in mental rotation and instrument interpretation in airline pilots. Sci Rep Jun 21;6:28104, 2016.

Peer-reviewed Conference Abstracts (* Talk)

Tik M, Woletz M, Princic M, Schuler A, Geissberger N, Hummer A, Windischberger A. Individualizing Brainstimulation through concurrent TMS/fMRI. 3rd International Brain Stimulation Conference - Vancouver, Canada. 2019.

Tik M, Woletz M, G Kranz, D Pfabigan, N Geissberger, R Sladky, C Kraus, B Auer, T Vanicek, K Paul, R Lanzenberger, C Lamm, Windischberger C. Remission from depression and tms over left DLPFC share the same network connectivity changes. 3rd International Brain Stimulation Conference - Vancouver, Canada. 2019.

Tik M, Woletz M, Princic M, Geissberger N, Schuler A, Hummer A, Windischberger C. Imaging Transcranial Magnetic Stimulation: Reconsidering Placebo Control. 26th Meeting of the Organization for Human Brain Mapping, HBM – Rome. 2019.

Tik M, Woletz M, Schuler A, Princic M, Pratapa A, Hummer A, Windischberger C. Explaining rTMS network effects by acute concurrent TMS/fMRI response. 26th Meeting of the Organization for Human Brain Mapping, HBM – Rome. 2019.

Tik M, Sladky R, Kranz G, Pfabigan D, Kraus G, Paul K, Reed S, Vanicek T, Auer B, Lanzenberger R, Lamm C, Windischberger C. Right SMG during emotion discrimination distinguishes depression from remission: A new TMS target?. 26th Meeting of the Organization for Human Brain Mapping, HBM – Rome. 2019.

Tik M, Woletz M, Schuler A, Princic M, Pratapa A, Hummer A, Windischberger C. Explaining rTMS network modulations by acute TMS/fMRI response*. Brain Stimulation and Imaging Meeting, BrainSTIM - Rome. 2019.

Tik M, Woletz M, Princic M, Schuler A, Geissberger N, Hummer A, Windischberger A. Individualizing Brainstimulation through concurrent TMS/fMRI. 3rd International Brain Stimulation Conference - Vancouver, Canada. 2019.

Tik M, Woletz M, G Kranz, D Pfabigan, N Geissberger, R Sladky, C Kraus, B Auer, T Vanicek, K Paul, R Lanzenberger, C Lamm, Windischberger C. Remission from depression and tms over left DLPFC share the same network connectivity changes. 3rd International Brain Stimulation Conference - Vancouver, Canada. 2019.

Woletz M, Tik M, M Prinčič, Schuler A, Windischberger C. EPI-based target tracking in concurrent TMS-fMRI. 3rd International Brain Stimulation Conference - Vancouver, Canada. 2019.

Woletz M, Tik M, N Pratapa, M Prinčič, Schuler A, Windischberger C. Real-time neuronavigation feedback in concurrent TMS-fMRI. 3rd International Brain Stimulation Conference - Vancouver, Canada. 2019.

Geissberger N, Tik M, Sladky R, Woletz M, Hoffmann A, Prinčič M, Windischberger C. The Necessity of Individualized TMS Targets: Inter-subject Variability of DLPFC Activation. 24th Meeting of the Organization for Human Brain Mapping, HBM – Singapore. 2018.

Tik M, Bukowski H, Schuler AL, Hummer A, Lamm C, Windischberger C. Theta burst stimulation of TPJ – a new potential target for depression treatment. 24th Meeting of the Organization for Human Brain Mapping, HBM – Singapore. 2018.

Tik M, Woletz M, Prinčič M, Geissberger N, Schuler A, Hummer A, Windischberger C. Individual DLPFC Dose-Response Profiles through concurrent TMS/fMRI. 24th Meeting of the Organization for Human Brain Mapping, HBM – Singapore. 2018.

Tik M, Sladky R, Luft C, Willinger D, Hoffmann A, Banissy M, Bhattacharya J, Windischberger C. Creative Insight: The role of Nucleus accumbens and the dopaminergic mid-brain. 25th Meeting of the Organization for Human Brain Mapping, HBM – Singapore. 2018.

Tik M, Woletz M, Princic M, Geissberger N, Schuler A, Hummer A, Windischberger A. Individualizing Brainstimulation through concurrent TMS/fMRI*. Brain Stimulation and Imaging Meeting, BrainSTIM - Singapore. 2018.

Woletz M, Tik M, Prinčič M, Schuler A, Windischberger C. TMS target tracking in TMS-fMRI experiments. 24th Meeting of the Organization for Human Brain Mapping, HBM – Singapore. 2018.

Geissberger N, Sladky R, Tik M, Hoffmann A, Woletz M, Willinger D, Robinson S, Windischberger C. Explicit versus Implicit Emotion Processing: a 7 Tesla fMRI study. 23rd Meeting of the Organization for Human Brain Mapping, 2017.

Tik M, Woletz M, Navarro de Lara L, Sladky R, Hoffmann A, Schuler AL, Willinger D, Geissberger N, Hummer A, Windischberger C. Mapping TMS immediate effects by concurrent TMS/fMRI using a dedicated high-sensitivity coil array. 23rd Meeting of the Organization for Human Brain Mapping, HBM – Vancouver, 2017.

Tik M, Woletz M, Kranz G, Pfabigan D, Geissberger N, Sladky R, Kraus C, Auer B, Vanicek T, Paul K, Lamm C, Lanzenberger R, Windischberger C. Connectomic insights into depression and TMS as a treatment option *. 23rd Meeting of the Organization for Human Brain Mapping, HBM – Vancouver, 2017.

Tik M, Woletz M, Navarro de Lara L, Sladky R, Hoffmann A, Hummer A, Windischberger C. Mapping TMS local and remote immediate effects by concurrent TMS/fMRI using a dedicated high-sensitivity coil array *. The triple M approach: Mapping, Modeling and Modulation in brain stimulation research @ 2nd International Brain Stimulation Conference - Barcelona, 2017.

Tik M, Woletz M, Navarro de Lara L, Sladky R, Hoffmann A, Hummer A, Windischberger C. Insights into depression and TMS as a treatment option. Brain Stimulation and Imaging Meeting, BrainSTIM - Vancouver, 2017.

Tik M, Woletz M, Navarro de Lara L, Sladky R, Hoffmann A, Hummer A, Geissberger N, Windischberger C. Mapping TMS immediate effects by concurrent TMS/fMRI using a dedicated high-sensitivity coil array. 25th Annual Meeting of the International Society for Magnetic Resonance Imaging, ISMRM - Honolulu, Hawaii, 2017.

Tik M, Woletz M, Hummer A, Geissberger N, Windischberger C. Individualized Thresholds: Calibrating brain stimulation through concurrent TMS/fMRI. 2nd European Conference on Brain Stimulation in Psychiatry, ECBSP - Munich, 2017.

Geissberger N, Sladky R, Tik M, Woletz M, Hoffmann A, Willinger D, Windischberger C. High BOLD stability of emotional faces processing network in ultra-high field fMRI data. Restingstate and Brain Connectivity, 2016.

Geissberger N, Tik M, Sladky R, Woletz M, Hoffmann A, Willinger D, Windischberger C. Reliability of Amygdala fMRI at Ultra-High Field. Organization for Human Brain Mapping Alpine Chapter, 2016.

Tik M, Sladky R, Luft CDB, Hoffmann A, Willinger D, Banissy M, Bhattacharya J, Windischberger C. Aha! Moments Inside: Self-arising creative solutions specified. 22nd Meeting of the Organization for Human Brain Mapping, HBM – Geneva, 2016.

Tik M, Woletz M, Navarro de Lara L, Sladky R, Hoffmann A, Hummer A, Windischberger C. Multimodal assessment of TMS-induced acute effects *. 6th International Conference on Transcranial Brain Stimulation - Göttingen, 2016.

Tik M, Hoffmann A, Sladky R, Tomova L, Hummer A, Navarro de Lara L, Biswal B, Bukowski H, Pripfl J, Lamm C, Windischberger C. Assessing effectiveness and specificity of DLPFC rTMS using an unbiased resting-state approach. 6th International Conference on Transcranial Brain Stimulation - Göttingen, 2016.

Tik M, Woletz M, Navarro de Lara L, Sladky R, Hoffmann A, Hummer A, Windischberger C. Multimodal assessment of TMS acute and long-term changes *. Brain Stimulation and Imaging Meeting, BrainSTIM - Geneva, 2016.

Hummer A, Ritter M, Tik M, Ledolter A, Schmidt-Erfurth U, Windischberger C. ICA-based denoising of population receptive field maps. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Hummer A, Ritter M, Tik M, Ledolter A, Schmidt-Erfurth U, Windischberger C. Eyetracker-based gaze correction for robust mapping of population receptive fields. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Navarro di Lara L, Tik M, Woletz M, Bukowski H, Stürkat IL, Lamm C, Moser E, Windischberger C. Boosting the sensitivity of concurrent TMS/fMRI in motor cortex using a dedicated MR coil array. 1th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Sladky R, Hahn A, Stürkat IL, Hoffmann A, Kranz G, Tik M, Seiger R, Pfabigan D, Lanzenberger R, Lamm C, Windischberger C. Modeling effective connectivity in the extended emotion processing network using DCM at 7T. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Sladky R, Kraus C, Stürkat IL, Hoffmann A, Lamplmair D, Tik M, Spies M, Pfabigan D, Lamm C, Lanzenberger R, Windischberger C. Effective connectivity of amygdala sub regions and OFC in acute and remitted MDD patients at 7T. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Sladky R, Stepniczka I, Tik M, Hoffmann A, Buch JP, Lamm C, Niedermeier D, Field J, Windischberger C. Manual control vs. automation monitoring: Inflight decision making in airline pilots. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Sladky R, Stepniczka I, Tik M, Lamm C, Hoffmann A, Niedermeier D, Field J, Windischberger C. Neurobiological differences in mental rotation and instrument interpretation in pilots. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Stepniczka I, Sladky R, Tik M, Lamm C, Hoffmann A, Niedermeier D, Field J, Windischberger C. Brain Mapping in Aircraft Pilots in-flight: Monitoring and Anticipation in challenging Situations. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Tik M, Sladky R, Di Bernardi Luft C, Hoffmann A, Hummer A, Banassy M, Bhattacharya J, Windischberger C. Ultra-high field fMRI insights on insight: Neural correlates of the “Aha!”-moment. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Tik M, Hoffmann A, Sladky R, Tomova L, Hummer A, Navarro di Lara L, Biswal B, Pripfl J, Lamm C, Windischberger C. 10Hz rTMS over the left DLPFC specifically modulates ACC connectivity within IC network 17. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.

Tik M, Woletz M, Lucia Navarro de Lara, Sladky R, Hoffmann A, Hummer A, Windischberger C. Multimodal Assessment of Local and Remote TMS-induced Effects. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.